No skin care routine is complete without antioxidant protection, especially when trying to combat premature ageing.
Lipochroman™ (INCI: Dimethylmethoxy Chromanol) molecule by Lubrizol Life Science Beauty is a bio-inspired molecule and antioxidant active ingredient with proven efficacy against oxidative stress, which is greater than other well-known agents such as resveratrol, vitamins E and C.
Reactive species have high chemical reactivity and can be based on oxygen (ROS), nitrogen (RNS) or carbonyl (RCS). When these reactive species accumulate in the skin, they may damage skin cells and structural components to contribute to the development of signs of skin ageing, which include wrinkles, loss of elasticity and age spots. To avoid the deleterious effects of reactive species, the skin possesses a system of endogenous defenses, such as low-molecularweight antioxidants, co-enzyme Q10 and vitamins C and E, which directly quench ROS.1 Additionally, there are small proline-rich repeat proteins (SPRRs), located in the stratum corneum, which have a direct role in scavenging ROS.2 Skin cells also rely on enzymatic detoxification systems that are responsible for the removal of ROS and xenobiotics. Dimethylmethoxy Chromanol, which is commercially available as an oil-soluble powder or as a water-soluble ingredient is a powerful bio-inspired antioxidant that can offer triple protection against ROS, RNS and RCS. Indeed, both cosmetic active ingredients demonstrate outstanding antioxidative properties in an aqueous solution, even compared to vitamin C (see figure 1). In addition, the active ingredient can boost the cell’s processes of detoxification of toxic substances coming both from the interior of the body and external environment. Thanks to the combined mechanism of action, the active ingredient can help to improve skin’s appearance. This was measured on a panel of 20 female volunteers (33 to 57 years old), who applied a cream containing 0.05% Dimethylmethoxy Chromanol or a placebo in a half-face experiment.
